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Amino acid and lipid metabolism in post-gestational diabetes and progression to type 2 diabetes: A metabolic profiling study.

PLoS Med. 2020 May;17(5):e1003112

Authors: Lai M, Liu Y, Ronnett GV, Wu A, Cox BJ, Dai FF, Rst HL, Gunderson EP, Wheeler MB

AbstractBACKGROUND: Women with a history of gestational diabetes mellitus (GDM) have a 7-fold higher risk of developing type 2 diabetes (T2D) during midlife and an elevated risk of developing hypertension and cardiovascular disease. Glucose tolerance reclassification after delivery is recommended, but fewer than 40% of women with GDM are tested. Thus, improved risk stratification methods are needed, as is a deeper understanding of the pathology underlying the transition from GDM to T2D. We hypothesize that metabolites during the early postpartum period accurately distinguish risk of progression from GDM to T2D and that metabolite changes signify underlying pathophysiology for future disease development.METHODS AND FINDINGS: The study utilized fasting plasma samples collected from a well-characterized prospective research study of 1,035 women diagnosed with GDM. The cohort included racially/ethnically diverse pregnant women (aged 20-45 years-33% primiparous, 37% biparous, 30% multiparous) who delivered at Kaiser Permanente Northern California hospitals from 2008 to 2011. Participants attended in-person research visits including 2-hour 75-g oral glucose tolerance tests (OGTTs) at study baseline (6-9 weeks postpartum) and annually thereafter for 2 years, and we retrieved diabetes diagnoses from electronic medical records for 8 years. In a nested case-control study design, we collected fasting plasma samples among women without diabetes at baseline (n = 1,010) to measure metabolites among those who later progressed to incident T2D or did not develop T2D (non-T2D). We studied 173 incident T2D cases and 485 controls (pair-matched on BMI, age, and race/ethnicity) to discover metabolites associated with new onset of T2D. Up to 2 years post-baseline, we analyzed samples from 98 T2D cases with 239 controls to reveal T2D-associated metabolic changes. The longitudinal analysis tracked metabolic changes within individuals from baseline to 2 years of follow-up as the trajectory of T2D progression. By building prediction models, we discovered a distinct metabolic signature in the early postpartum period that predicted future T2D with a median discriminating power area under the receiver operating characteristic curve of 0.883 (95% CI 0.820-0.945, p < 0.001). At baseline, the most striking finding was an overall increase in amino acids (AAs) as well as diacyl-glycerophospholipids and a decrease in sphingolipids and acyl-alkyl-glycerophospholipids among women with incident T2D. Pathway analysis revealed up-regulated AA metabolism, arginine/proline metabolism, and branched-chain AA (BCAA) metabolism at baseline. At follow-up after the onset of T2D, up-regulation of AAs and down-regulation of sphingolipids and acyl-alkyl-glycerophospholipids were sustained or strengthened. Notably, longitudinal analyses revealed only 10 metabolites associated with progression to T2D, implicating AA and phospholipid metabolism. A study limitation is that all of the analyses were performed with the same cohort. It would be ideal to validate our findings in an independent longitudinal cohort of women with GDM who had glucose tolerance tested during the early postpartum period.CONCLUSIONS: In this study, we discovered a metabolic signature predicting the transition from GDM to T2D in the early postpartum period that was superior to clinical parameters (fasting plasma glucose, 2-hour plasma glucose). The findings suggest that metabolic dysregulation, particularly AA dysmetabolism, is present years prior to diabetes onset, and is revealed during the early postpartum period, preceding progression to T2D, among women with GDM.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01967030.

PMID: 32433647 [PubMed as supplied by publisher]

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Amino acid and lipid metabolism in post-gestational diabetes and progression to type 2 diabetes: A metabolic profiling study. - DocWire News

The result is dry, or very dry, rough, and tight skin, which can progress to become extremely rough and scaly, flaky and itchy.

While assessing for predictors of foot lesions in patients with type 2 diabetes, health experts also found that 82.1 percent of patients with the condition had skin with dryness, cracks, and fissures.

Xerosis is a common condition experienced by millions of people, either chronically or acutely.

In a study with the US National Library of Medicine National Institutes of Health, skin disorders in diabetes mellitus was investigated.

The study noted: Skin disorders, usually neglected and frequently underdiagnosed among diabetic patients, are common complications and encounter a broad spectrum of disorders in both type 1 and type 2 diabetes.

Skin disorders are highly associated with increased risk of important outcomes, such as skin lesions, ulcerations and diabetic foot, which can lead to major complications and revolve around multifactorial factors besides hyperglycaemia and advanced glycation end products.

Differences between patterns of lesions remain unclear among types of diabetes.

A total of five studies evaluated skin disorders in both types 1 and 2 diabetes and showed higher prevalence of skin disorder in type 2 diabetes.

Most frequent disorders presented in patients with type 2 DM were infections, xerosis, hair loss below the knees and diabetic dermopathy.

Diabetes.co.uk said on their website: Skin care is an important factor for people with diabetes.

Skin conditions can be more likely amongst diabetics, and reduced sensitivity of nerves and circulation can often make it harder to spot emerging skin problems.

The skin on our feet need particular attention as the presence of diabetic neuropathy can sometimes lead to skin issues not being identified until at an advanced stage, when they can cause serious problems.

People with diabetes may experience greater loss of fluid from the body due to high blood glucose levels, which can cause dry skin on the legs, elbows, feet and other areas of the body.

If the skin becomes cracked, germs can get into these areas and cause infection, meaning that taking care of the skin is essential.

If you notice your skin become severely dry it's important to speak with your GP abou the possible cause.

More:
Type 2 diabetes: Xerosis is a warning your blood sugar levels are high what it is - Express

The report on the Diabetes Software market provides a birds eye view of the current proceeding within the Diabetes Software market. Further, the report also takes into account the impact of the novel COVID-19 pandemic on the Diabetes Software market and offers a clear assessment of the projected market fluctuations during the forecast period. The different factors that are likely to impact the overall dynamics of the Diabetes Software market over the forecast period (2019-2029) including the current trends, growth opportunities, restraining factors, and more are discussed in detail in the market study.

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The Diabetes Software market report Elucidated with regards to the regional landscape of the industry:

The geographical reach of the Diabetes Software market has been meticulously segmented into United States, China, Europe, Japan, Southeast Asia & India, according to the report.

The research enumerates the consumption market share of every region in minute detail, in conjunction with the production market share and revenue.

Also, the report is inclusive of the growth rate that each region is projected to register over the estimated period.

The Diabetes Software market report Elucidated with regards to the competitive landscape of the industry:

The competitive expanse of this business has been flawlessly categorized into companies such as

Regional and Country-level AnalysisThe report offers an exhaustive geographical analysis of the global Diabetes Software market, covering important regions, viz, North America, Europe, China, Japan, Southeast Asia, India and Central & South America. It also covers key countries (regions), viz, U.S., Canada, Germany, France, U.K., Italy, Russia, China, Japan, South Korea, India, Australia, Taiwan, Indonesia, Thailand, Malaysia, Philippines, Vietnam, Mexico, Brazil, Turkey, Saudi Arabia, U.A.E, etc.The report includes country-wise and region-wise market size for the period 2015-2026. It also includes market size and forecast by each application segment in terms of revenue for the period 2015-2026.Competition AnalysisIn the competitive analysis section of the report, leading as well as prominent players of the global Diabetes Software market are broadly studied on the basis of key factors. The report offers comprehensive analysis and accurate statistics on revenue by the player for the period 2015-2020. It also offers detailed analysis supported by reliable statistics on price and revenue (global level) by player for the period 2015-2020.On the whole, the report proves to be an effective tool that players can use to gain a competitive edge over their competitors and ensure lasting success in the global Diabetes Software market. All of the findings, data, and information provided in the report are validated and revalidated with the help of trustworthy sources. The analysts who have authored the report took a unique and industry-best research and analysis approach for an in-depth study of the global Diabetes Software market.The following players are covered in this report:GlookoAccu-Chek (Roche)TidepoolLifeScan, Inc (Platinum Equity)Pharmaco DiabetesAscensia Diabetes Care Holdings AGDiabeto Medtech India Pvt. LtdAbbott Diabetes CareAcon Diabetes Care InternationalBIONIMECusto medDexcomDottliGlucoMeMyLifeNovaTandem Diabetes CareTrividia HealthDiabetes Software Breakdown Data by TypeFor SmartphonesFor Tablet PCWeb-basedDiabetes Software Breakdown Data by ApplicationType 1 DiabetesType 2 Diabetes

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Exclusive details pertaining to the contribution that every firm has made to the industry have been outlined in the study. Not to mention, a brief gist of the company description has been provided as well.

Substantial information subject to the production patterns of each firm and the area that is catered to, has been elucidated.

The valuation that each company holds, in tandem with the description as well as substantial specifications of the manufactured products have been enumerated in the study as well.

The Diabetes Software market research study conscientiously mentions a separate section that enumerates details with regards to major parameters like the price fads of key raw material and industrial chain analysis, not to mention, details about the suppliers of the raw material. That said, it is pivotal to mention that the Diabetes Software market report also expounds an analysis of the industry distribution chain, further advancing on aspects such as important distributors and the customer pool.

The Diabetes Software market report enumerates information about the industry in terms of market share, market size, revenue forecasts, and regional outlook. The report further illustrates competitive insights of key players in the business vertical followed by an overview of their diverse portfolios and growth strategies.

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Some of the Major Highlights of TOC covers:

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Assessing the Fallout From the Coronavirus Pandemic Diabetes Software Market 2019- Industry Analysis by Size, Share Leaders, Growth Opportunities,...

Cuts and abrasions are a part of life and all of us deal with this on a daily. Most of us dont even think much of it as minor injuries heal fast and does not even leave a mark. A quick application of first aid and you are done. But the same is not true if you have diabetes. Diabetic wounds fall in a different category altogether. Also Read - Diabetes alert: Beware of dementia and cancer if you have elevated blood sugar levels

If you have diabetes, you may have noticed that it takes a long time for wounds to heal. In fact, the higher your blood sugar levels, the more time it takes for wounds to heal. Moreover, because of diabetic neuropathy, you may also not notice injuries on your feet. The numbness on your feet can lead to a false sense of security that everything is all right. It is, therefore, very important to take care off any cuts and injuries that you may have if you have diabetes. Any neglect on your part can lead to unwanted complications that can be easily avoided. Your feet are more at risk. So, you have to take extra care of your feet if you have diabetes. Also Read - Diabetes checklist: Are you making these glucometer mistakes while checking blood sugar at home?

You need to make this a part of your daily ritual. Check your body carefully for any signs of cuts, blisters and swelling in your feet. You must be extra alert if you have loss of sensation in your feet. This is common in diabetes. Any neglect on your part may lead to amputations. In fact, this is a very common complication of diabetes. If you have any cuts or abrasions in any other part of your body, apply first aid. If it does not help, consult a doctor. Also Read - Can people with diabetes keep fast during Ramadan?

Proper dressing is important and you need to change it at regular intervals. This will help the wound to heal faster as clean and proper dressing will maintain the moisture level around the wound. Not doing so will delay the healing process. It will also increase your risk of secondary infections. Learn how to do this properly from your doctor.

The higher your blood sugar levels, the longer it will take for your wounds to heal. So you need to take proper care of your diabetes and keep it under control. If you can do so, it will hasten the healing process. Follow a healthy diet and get your daily requirement of proteins, vitamins, minerals and zinc. Have more vitamin c rich foods. All this will help you maintain your blood sugar levels and would will notice your wounds healing faster.

This stimulates circulation. It will stimulate blood flow to the legs and keep numbness away. So be sure to follow a daily exercise routine. You dont have to go to a gym for this. Go for a walk, do some yoga or work out at home. Any physical activity will help.

Published : May 23, 2020 8:06 pm

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Know how to deal with wounds if you have diabetes - TheHealthSite

"For those who are shielding, particularly if they do not need to, the psychological and emotional impact could be significant, while the stress and restrictions to movement could equally have an impact on someones overall health and wellbeing and, specifically, their blood glucose control. But it is incredibly important that the Government uses the latest data to inform their advice, to ensure that the guidelines around shielding are not only proportionate, but also in direct response to the data available.

"We understand that Nervtag will review the evidence for shielding, including what evidence is emerging about who is at highest clinical risk of severe illness if they catch Covid-19. This will inform the future of the shielding programme."

Meanwhile, Public Health England has begun a review examining how obesity, along with genderand ethnicity, can affect health outcomes. Overall, 29 per cent of adults of all ages are obese, compared with an average of 19.5 in the latest international audit by the Organisation for Economic Co-operation and Development. Analysis in 2017 revealed the UK as the fattest nation in Western Europe, with obesity rates twice those of countries including Sweden and Norway.

A Department of Health and Social Care spokeswoman said: The guidance on shielding and protecting people who are clinically extremely vulnerable from Covid-19 has been developed by expert doctors. They have identified specific medical conditions that, based on what we know about the virus so far, place someone at greatest risk of severe illness from Covid-19. We continue to keep this evidence under review.

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Diabetics may be forced to self-isolate at home after lockdown is lifted, government review suggests - Telegraph.co.uk

Diabetes can show up in many different waysand some of them are easy to miss. In fact, of the 30 million Americans who have diabetes, nearly one-quarter of them dont know it. Thats why paying attention to early signs is so important. If diabetes runs in your family or the symptoms below sound familiar, its probably a good time to check in with your doctor. Early and accurate diagnosis will give you a head start at beating this disease.

Diabetes mellitus is a disorder that causes people to have higher-than-normal levels of sugaror, glucosein their blood. There are three main types of diabetes: type 1, type 2, and gestational diabetes.

Heres how it happens: After you eat a meal, your food is broken down into glucose (among other things) that serves as your entire bodys source of energy. Glucose enters the bloodstream and in response your pancreas releases insulin, a hormone that helps move glucose into fat and muscle cells so they can use it for energy.

In people with diabetes, though, glucose struggles to get out of your blood. This is because either your pancreas doesnt produce enough insulin to help move glucose into your cells (type 1 diabetes), or because your body isnt able to use insulin efficiently (type 2 and gestational diabetes), so you need to make more and more of it.

Either way, glucose begins to build up in the blood. Over time, high blood sugar causes inflammation and other major health troubles.

Despite their differing causes, type 1, type 2, and gestational diabetes have similar symptoms. But because signs of the disease are often mild and develop slowly, theyre easy to miss or dismiss.

There are two signature symptoms of the disease:

Thirst: When theres too much sugar in the bloodstream, your body pulls water from surrounding tissues to try to dilute it, leaving you dehydrated and parched. Some people with diabetes feel like no matter how much they drink, they cant quench their thirst.

Frequent urination: Feeling thirsty makes you to drink more, increasing the need to pee. Plus, diabetes causes the kidneys to work overtime removing sugar from the blood. The kidneys dump this sugar into your urine, creating more pee. And in more advanced stages of the disease, damaged nerves around the bladder may cause some people to feel the urge to pee frequently, even if little or nothing comes out.

Kids with diabetes may suddenly start to have accidents at night or even during the day, even if theyve been potty trained for years.

Frequent urination and thirst often occur when blood sugar is already significantly elevated. But there are a few less obvious signs that can show up earlier on.

Fatigue and muscle weakness: Glucose is one of your bodys most important sources of energybut in diabetes, much of it remains in the bloodstream instead of nourishing your cells, making you feel tired.

Feeling hungrier: To try to get the energy it needs to function, your brain ramps up hunger signals and cravings. Eating more doesnt help, though, because the glucose from the food remains trapped in the bloodstream.

Along with feelings of thirst and hunger, as well as fatigue and the frequent need to pee, there are other clues that could possibly indicate diabetes. As always, having one or more of these symptoms doesnt mean you have the disease. But its a good idea to see a doctor to have things checked out if you are experiencing:

Headaches: When you body finds itself short of the glucose it needs to function, your central nervous system may send pain signals, in the form of headaches, as a warning sign. In addition, dehydration from excessive urination may also lead to headache pain, although the exact mechanism remains unclear. Also, high blood sugar may lead to increased production of epinephrine and norepinephrine, hormones that can constrict blood vessels in the brain, causing headaches.

Weight Loss: Some people, especially those with type 1 diabetes, may experience unexpected weight loss, even though they are eating more. When insulin is lacking or there is resistance to it, your body breaks down more fat, causing you to shed pounds.

Rash: People with diabetes are more likely to get fungal skin infections from organisms like yeast. An overgrowth of yeast on the skin can trigger an itchy, scaly rash in warm nooks and crannies like the underarms or between the toes.

Skin Changes: In type 2 diabetes, your pancreas pumps out large amounts of insulin to try and move glucose from your blood into your bodys cells for energy. High levels of insulin can cause skin cells to multiply rapidly, resulting in darkened, velvety-feeling patches of skin called acanthosis nigricans. They can occur anywhere on your body, but are often found in skinfolds of the neck, groin, or armpit.

Ketoacidosis: In an effort to get the fuel it needs, your body may start to break down its own fat stores. This floods the bloodstream with substances called ketones, making the blood acidic and become toxic. Ketoacidosis causes shortness of breath, confusion, extreme fatigue, and nausea, and requires immediate treatment. Its more common in type 1 diabetes, but it can also happen in people with type 2.

Numbness: The longer blood sugar stays highand the higher it spikesthe more damage is done to nerves, blood vessels, and other organs in the body. Over time, excess blood sugar can damage nerve endings and lead to tingling, burning, or numbness in the fingers and toes.

Diarrhea: Sometimes high blood sugar can damage nerves in the intestinal tract. If this kind of damagecalled autonomic neuropathyhappens, a person might swing back and forth between periods of diarrhea and constipation.

The U.S. Preventive Services Task Force recommends that anyone over age 40 with a BMI of 25 or more should be screened for diabetes, then checked every three years thereafter. People with additional risk factorslike a strong family history of diabetes or autoimmune disordersshould be screened earlier and more often.

The first step in getting a diabetes diagnosis is a blood test. If you are diagnosed with the disease, your doctor may want to perform additional tests to find out which type it is. Correct diagnosis is important since treatment differs for the different types.

Your doctor may want to test your urine for ketones, chemicals your body produces when it has to break down fat for energy. The test can generally be done at home, or in a lab or doctors office by peeing into a specimen cup. If youre doing the test at home, it will come with paper test strips to dip into the urine.

Extremely high levels of ketones are a sign of ketoacidosis, a potentially fatal complication of diabetes that requires emergency treatment. Ketones usually happen in type 1 diabetes, but on rare occasions, it can occur with type 2, too.

The good news, no matter what your symptoms may be, is that if you do have diabetes, the disease is highly manageable. Through daily insulin injections, medications, and modifications to your diet and exercise routine, you can stay one step ahead of this condition.

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Diabetes Signs, Symptoms, and Testing - HealthCentral.com

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Stem Cells Green Healthcare Costa Rica

Stem Cell Treatment for COPD in and around Costa Rica

About Costa Rica

Costa Rica is a great place to be adventurous or for those who just want to relax and unwind. With more than 1,000 miles of coastline, the country is home to some of the world's most beautiful beaches(If you are looking for lots of sun, avoid the rainy season, between April and November). It is one of the top surfing destinations in the world, the water is warm year-round.

With its own delicious national cuisine, the country is also a huge grower of coffee, bananas and chocolate. If you visit Quepos, be sure to take a tour at Villa Vanilla farms to see how they make chocolate as well as vanilla, pepper, cinnamon and more. It is known as the happiest country on Earth. A common saying among locals is pura vida, which means pure life. Everywhere you go in Costa Rica, you will be welcomed with a smile by the locals. About 25% of the Costa Rica is made up of protected national parks and rainforests which hold 5% of the world's biodiversity and the country has very rich and fertile soil which helps make it so lush and full of life. The volcanoes and surrounding areas are also popular areas for hiking, camping and mountain biking.

Costa Ricas has two JCI-accredited hospitals and numerous smaller, private AAAASF-accredited and AAAHC-accredited clinics offering a wide range of medical services, including orthopedics, cardiology, cosmetic surgery, and bariatrics. Idyllic scenery and unique recovery lodges which has made Costa Rica a prime destination for the medical tourists,many of which travel for Stem Cell Treatment for COPD procedures.

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Stem Cell Treatment for COPD in Costa Rica - MyMediTravel

A bionic eye could restore sight to the blind and greatly improve robotic vision, but current visual sensors are a long way from the impressive attributes of natures design. Now researchers have found a way to mimic its structure and create an artificial eye that reproduces many of its capabilities.

A key part of what makes the eyes design so powerful is its shape, but this is also one of the hardestthings to mimic. The concave shape of the retinathe photoreceptor-laden layer of tissue at the back of the eyemakes it possible to pick up much more light as it passes through the curved lens than it would pick up if it was flat. But replicating this curved sensor array has proven difficult.

Most previous approaches have relied on fabricating photosensors on flat surfaces before folding them or transplanting them onto curved ones. The problem with this approach is that it limits the density of photosensors, and therefore the resolution of the bionic eye, because space needs to be left between sensors to allow the transformation from flat to curved.

In a paper published last week in Nature, though, researchers from Hong Kong University of Science and Technology devised a way to build photosensors directly into a hemispherical artificial retina. This enabled them to create a device that can mimic the wide field of view, responsiveness, and resolution of the human eye.

The structural mimicry of Gu and colleagues artificial eye is certainly impressive, but what makes it truly stand out from previously reported devices is that many of its sensory capabilities compare favorably with those of its natural counterpart, writes Hongrui Jiang, an engineer at the University of Wisconsin Madison, in a perspective in Nature.

Key to the breakthrough was an ingenious way of implanting photosensors into a dome-shaped artificial retina. The team created a hemisphere of aluminum oxide peppered with densely-packed nanoscale pores. They then used vapor deposition to grow nanowires inside these pores made from perovskite, a type of photosensitive compound used in solar cells.

These nanowires act as the artificial equivalent of photoreceptors. When light passes over them, they transmit electrical signals that are picked up by liquid metal wires attached to the back of the retina. The researchers created another hemisphere made out of aluminum with a lens in the center to act as the front of the eye, and filled the space in between it and the retina with an ionic liquid designed to mimic the fluid aqueous humor that makes up the bulk of the human eye.

The researchers then hooked up the bionic eye to a computer and demonstrated that it could recognize a series of letters. While the artificial eye couldnt quite achieve the 130-degree field of view of a human eye, it managed 100 degrees, which is a considerable improvement over the roughly 70 degrees a flat sensor can achieve.

In other areas, though, the approach has the potential to improve on biological eyes. The researchers discovered that the nanowires photodetectors were actually considerably more responsive. They were activated in as little as 19.2 milliseconds and recovered to a point where they could be activated again in 23.9 milliseconds. Response and recovery times in human photoreceptors range from 40 to 150milliseconds.

The density of nanowires in the artificial retina is also more than 10 times that of photoreceptors in the human eye, suggesting that the technology could ultimately achieve far higher resolution than nature.

The big limitation at the moment is wiring up these photosensors. The liquid metal connections are currently two orders of magnitude wider than the nanowires, so each one connects to many photosensors, and its only possible to attach 100 wires to the back of the retina. That means that despite the density of photosensors, the eye has a resolution of only 100 pixels.

The researchers did devise a way to use magnetic fields to connect nickel microneedles to just three nanowires at a time, but the process is a complicated manual one that would be impossible to scale up to the millions of nanowires present in the artificial retina. Still, the device represents a promising proof-of-concept that suggests that we may soon be able to replicate and even better one of natures most exquisite designs.

Given these advances, it seems feasible that we might witness the wide use of artificial and bionic eyes in daily life within the next decade, writes Jiang.

Image Credit: Free-Photos from Pixabay

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A New Bionic Eye Could Give Robots and the Blind 20/20 Vision - Singularity Hub

But I started having blurry vision, and it turned out it was because that freckle had started to grow across my pupil.

Diagnosed in 2005 at the age of 37, Ms Vine said the time after her diagnosis was a blur just like her vision before she was rushed for emergency surgery to have her eye removed.

An example of a uveal or eye melanoma forming on the iris.Credit:QIMR Berghofer

When I was diagnosed, I cried for days, she said.

It was devastating. I had two young children, it was a blur, I just went to scans and follow-ups and then before I knew it, surgery.

About 175 new cases of eye melanoma are diagnosed in Australia annually.

Ocular melanomas are more commonly found in the back of the eye and those found there often have worse outcomes for patients as they can spread quickly to other areas of the body, especially the brain.

Many patients will lose their sight in the affected eye as part of the treatment, which can involve radiation and laser therapy for small cancers, or removal of the eye for more advanced tumours.

Ms Vine was one of the 50 per cent of cases who do not see any subsequent cancers, and has remained cancer-free.

She agreed to be part of a new study at QIMR Berghofer medical research institute in an effort to find out more about the rare but deadly forms of cancer.

Previously it was thought that unlike skin melanomas, which are significantly affected by UV rays, eye melanomas were not affected by sunlight.

However, research from QIMR has found about 5 percent of ocular melanomas, mostly iris melanomas like Ms Vines, are at least partially caused by sunlight exposure.

QIMR ophthalmologist Dr Lindsay McGrath said that meant treatments which were previously thought to be ineffective against eye melanomas could be brought to bear.

Some of the immunotherapies which have been developed for skin melanomas might play more of a role in uveal melanoma which has spread outside the eye, Dr McGrath said.

At the moment we have no treatment for eye melanomas which spread beyond the eye, and patients have to get involved in clinical trials just for a chance at a treatment.

The researchers also discovered a common anti-cancer gene called TP53 was switched off in uveal melanomas, which has highlighted a further avenue for possible treatment in the future.

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The findings emphasise the importance of wearing UV-blocking sunglasses, Dr McGrath said.

Ms Vine said she hoped the research would allow other people to keep their eyes and their sight as new treatments are developed in the future.

People dont think about getting their eyes checked if they dont wear glasses, but it can save your life, she said.

Stuart Layt covers health, science and technology for the Brisbane Times. He was formerly the Queensland political reporter for AAP.

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In two weeks, Susan went from blurred vision to having an eye removed - Brisbane Times

A team of scientists at the Hong Kong University of Science and Technology have developed an artificial eye that could someday help cure blindness or even enhance human vision. For now, their creation boasts just 100-pixel resolution, but the groundwork has been laid.

The team, led by Leilei Gu, describe their creation in a paper published yesterday in the journal Nature. In that paper, Gu et al. describe an electrochemical eye with a hemispherical retina made of a high-density array of nanowires [that mimic] the photoreceptors on a human retina.

Build to be structurally similar to a real human eye, the spherical cyborg eye uses a 100 FOV lens (the human eye boasts a 130 FOV) to focus light onto a 2mm-wide area that features a densely packed array of photosensitive nanowires in lieu of the rods and cones in our own eyes. Just like in the human eye, the light travels through a space filled with, in this case, an ionic fluid before activating those photoreceptors and sending a signal further down the pipe using thin, flexible wires made of a liquid metal (eutectic galliumindium alloy) in lieu of nerve fibers.

Most impressive is that even the current prototype can match or even surpass the human eye in certain respects. According to a news report in Nature, the sensitivity to light of the artificial retina is already on par with the human eye, and the nanowires responsiveness is actually fasterthey can produce a response in 19.2ms and recover in as little as 23.9ms, compared to the 40-150ms response and recovery times of photo receptors in the human eye.

Where it falls (far) short is in overall resolution. Each pixel is made up of four nanowires, and the current version only boasts a 10 x 10 pixel resolution in that tiny 2mm-wide array. The nanowires themselves are tiny, but the liquid metal nerves are still too big. Manufacturing the current version is both expensive and slow, and the actual resilience of this design needs to be tested to determined how quickly the artificial retina breaks down. Finally, the current version needs external power, though scientists say this design could someday be solar powered.

Knowing all of this, were obviously a ways away from curing blindness with cyborg eyes, much less improving on human vision with eye upgrades that could extend our visual awareness beyond the traditional visible light spectrum. But a waysthe Nature report imagines real-life use as soon as within the next decadeis a far sight sooner than most of us can even fathom for a technology straight out of science fiction.

To read up on this breakthrough in more detail, check out the news report on the Nature website. And if you have a subscription to the journal, you can read the full research paper at this link.

(via New Scientists via Engadget)

Image credits: Header photo by Harry Quan, CC0

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Researchers Have Created a Cyborg Eye that Works Like the Real Thing - PetaPixel

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A new paper in Cell describes a radical treatment that may give the visually impaired the ability to see again. Using a visual cortical prosthesis (VCP) implanted on the brain, researchers were able to stimulate figures which allowed subjects to see the figure via electrical impulses.

This procedure produces a small flash of lightknown as a phosphenewithout any light actually entering their eyes. For example, the lights you see when you rub your eyes are classified as mechanical phosphenes.

Study subjects included sighted and blind participants who reported what they were seeing as researchers traced shapes on the surface of the brain's visual cortex by stimulating electrodes in dynamic sequence. Blind participants recognized the shapes being drawneven as they appeared at a speedy 86 forms per minute. The researchers also note that their findings support the use of a brain prosthesis in order to restore some semblance of vision in the blind.

In this case, the visual cortex is the best location for a VCP as it's the area of the brain that processes information from the eyes. In the 1960s, researchers kind of had the right idea when they theorized that stimulating certain spots of the cortex might help the blind see thanks to the phosphene phenomena. What they got wrong was the assumption that stimulating individual spots would create a cohesive picture in the mind's eye.

According to study authors Michael Beauchamp, a neuroscientist, and Daniel Yoshor, a neurosurgeon, our brains are wildly complex and for reasons that we don't yet fully understand, it is actually very difficult to produce recognizable forms from phosphene combinations. Still, the researchers managed to find a way around this as they conducted their research. In the study they write:

Beauchamp et al.

Although it seems promising, this kind of technology is still in its infancy and will require time for further development. This initial study only utilized a couple of electrodes whereas thousands would be needed to "paint" a better pictures for those using the tech. Additionally, durable electrodes that are compatible with our biology will need to be created for long-term use and implantation in order to help the visually impaired see again.

We're not quite there yet, but we seem to be going in the right direction.

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'Brain Drawing' Could Help Give the Blind a Sense of Sight - Popular Mechanics

People are going blind for thelack of basic eye checks as they are too afraid to travel to a hospital or optician.

Specialist doctors have told the Telegraph that people risk irreparable damage to their eyes as waiting rooms which were usually full, are now almost empty.

One eye clinic reported that half of their patients with macular degeneration are failing to attend essential treatment, without which they will go blind.

One doctor told the Telegraph that he had seen a drop off of around 90 per cent, and that it had been four or five weeks since he had seen a single patient referred for their first vital appointment after being referred from an optician.

Patients with wet type macular degeneration, need to be seen regularly in the eye clinic to decide if they need the injections, and to be treated so that the vision stabilates at that level, said Professor Sobha Sivaprasad, consultant ophthalmologist at Moorfields Eye Hospital.

If they don't attend these visits then it will have a lasting impact on their sight. These conditions are sight-threatening

In a clinic we'd see about 100 patients each day and was always overbooked, half of those were not coming in.

They're not coming in because of fear - whether that's of public transport, getting the infection just getting out of their house.

Macular diseases are by far the biggest cause of sight loss in the UK, with nearly 1.5m people estimated to be living with some form of the condition.

Every day, around 300 people are diagnosed with macular disease. It can affect people of any age even children and there is still no cure.

Cilla Shell worked for 14 years in clinical governance within the NHS. The 68 year-old from Hornchurch said that she was scared to go to hospital for her routine appointments.

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People going blind as they are 'too scared' to see a doctor or optician - Telegraph.co.uk

Hopefully soon we will be back to dealing with such now-rarely-mentioned dangers as climate change which some have even called the next pandemic the threat of a nuclear disaster, our crumbling infrastructure, and the failing health care system, among others. Those may seem insignificant today, but they are not going away. Indeed, none of the problems America faced before COVID-19 are going away. The temporary paralysis caused by our focus on COVID-19 is only making them worse.

Thats why it is so important that who we elect in November has a specific plan to address the big issues we face. We need a strategy. The next president whether it is the current one or his opponent must articulate specific and practical solutions ones which can generate support among Republicans, Democrats and independents.

And like the doctors and other health care professionals dealing with COVID-19, our would-be president must base his plans on facts and data, not wishful thinking or blind loyalty to rigid political ideologies.

Thats what good government means. In terms of human life, opportunities squandered and economics, we are paying an incalculable price for the bad government that kept its head in the sand and denied the threat of COVID-19 for the important months of December, January, February and half of March. By any definition it is a debacle. If we have learned anything during the COVID-19 pandemic, it is that good government matters.

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John Burke: One eye on the forest, one eye on the trees - Madison.com

(MENAFN - Khaleej Times) What is the price of a smile? Now multiply that by 71 million. For, that's the number of lives that the Mohammed Bin Rashid Al Maktoum Global Initiatives touched and transformed in 2019. agratitude from around the world. In this series, Khaleej Times showcases eight people whose lives MBRGI changed last year through the power of hope

El Hadj Habib Cisse, 74, lives in the rural town of Mekhe, Senegal, home to 33,000 residents who do not have access to basic healthcare services. The town does not have a licensed hospital that provides routine medical services, such as eye examinations and vision treatment.

Cisse used to work as a tailor before developing cataracts more than 20 years ago. His eyesight diminished gradually until he could no longer see well enough to perform his most basic daily tasks, let alone continue working. As a result, he lost his only source of income.

Due to the lack of resources in his hometown and his meagre living conditions, Cisse was unable to get the proper treatment for his cataracts. Then Noor Dubai's mobile eye camp brought a ray of hope into his life.

isse was one of the 2,158 patients who received critical eye surgeries as part of Noor Dubai's four medical camps in Senegal and Bangladesh last year. The mobile camps provided medical services to 20,486 patients and distributed 6,608 pairs of eyeglasses in remote areas of both countries.

Thanks to the medical team, Cisse's eyesight was restored, enabling him to lead a productive life today with an income of his own.

MENAFN2205202000490000ID1100208263

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#PowerOfHope: Surgery gave back tailor his eyesight - and work - MENAFN.COM

The report on the Mesenchymal Stem Cells market provides a birds eye view of the current proceeding within the Mesenchymal Stem Cells market. Further, the report also takes into account the impact of the novel COVID-19 pandemic on the Mesenchymal Stem Cells market and offers a clear assessment of the projected market fluctuations during the forecast period. The different factors that are likely to impact the overall dynamics of the Mesenchymal Stem Cells market over the forecast period (2019-2029) including the current trends, growth opportunities, restraining factors, and more are discussed in detail in the market study.

The Mesenchymal Stem Cells market study is a well-researched report encompassing a detailed analysis of this industry with respect to certain parameters such as the product capacity as well as the overall market remuneration. The report enumerates details about production and consumption patterns in the business as well, in addition to the current scenario of the Mesenchymal Stem Cells market and the trends that will prevail in this industry.

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What pointers are covered in the Mesenchymal Stem Cells market research study?

The Mesenchymal Stem Cells market report Elucidated with regards to the regional landscape of the industry:

The geographical reach of the Mesenchymal Stem Cells market has been meticulously segmented into United States, China, Europe, Japan, Southeast Asia & India, according to the report.

The research enumerates the consumption market share of every region in minute detail, in conjunction with the production market share and revenue.

Also, the report is inclusive of the growth rate that each region is projected to register over the estimated period.

The Mesenchymal Stem Cells market report Elucidated with regards to the competitive landscape of the industry:

The competitive expanse of this business has been flawlessly categorized into companies such as

Regional and Country-level AnalysisThe report offers an exhaustive geographical analysis of the global Mesenchymal Stem Cells market, covering important regions, viz, North America, Europe, China, Japan, Southeast Asia, India and Central & South America. It also covers key countries (regions), viz, U.S., Canada, Germany, France, U.K., Italy, Russia, China, Japan, South Korea, India, Australia, Taiwan, Indonesia, Thailand, Malaysia, Philippines, Vietnam, Mexico, Brazil, Turkey, Saudi Arabia, UAE, etc.The report includes country-wise and region-wise market size for the period 2015-2026. It also includes market size and forecast by each application segment in terms of revenue for the period 2015-2026.Competition AnalysisIn the competitive analysis section of the report, leading as well as prominent players of the global Mesenchymal Stem Cells market are broadly studied on the basis of key factors. The report offers comprehensive analysis and accurate statistics on revenue by the player for the period 2015-2020. It also offers detailed analysis supported by reliable statistics on price and revenue (global level) by player for the period 2015-2020.On the whole, the report proves to be an effective tool that players can use to gain a competitive edge over their competitors and ensure lasting success in the global Mesenchymal Stem Cells market. All of the findings, data, and information provided in the report are validated and revalidated with the help of trustworthy sources. The analysts who have authored the report took a unique and industry-best research and analysis approach for an in-depth study of the global Mesenchymal Stem Cells market.The following players are covered in this report:LonzaThermo FisherBio-TechneATCCMilliporeSigmaPromoCell GmbHGenlantisCelprogenCell ApplicationsCyagen BiosciencesMesenchymal Stem Cells Breakdown Data by TypeHuman MSCMouse MSCRat MSCOtherMesenchymal Stem Cells Breakdown Data by ApplicationResearch InstituteHospitalOthers

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Exclusive details pertaining to the contribution that every firm has made to the industry have been outlined in the study. Not to mention, a brief gist of the company description has been provided as well.

Substantial information subject to the production patterns of each firm and the area that is catered to, has been elucidated.

The valuation that each company holds, in tandem with the description as well as substantial specifications of the manufactured products have been enumerated in the study as well.

The Mesenchymal Stem Cells market research study conscientiously mentions a separate section that enumerates details with regards to major parameters like the price fads of key raw material and industrial chain analysis, not to mention, details about the suppliers of the raw material. That said, it is pivotal to mention that the Mesenchymal Stem Cells market report also expounds an analysis of the industry distribution chain, further advancing on aspects such as important distributors and the customer pool.

The Mesenchymal Stem Cells market report enumerates information about the industry in terms of market share, market size, revenue forecasts, and regional outlook. The report further illustrates competitive insights of key players in the business vertical followed by an overview of their diverse portfolios and growth strategies.

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Some of the Major Highlights of TOC covers:

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Impact of COVID-19 Outbreak on Mesenchymal Stem Cells Market: Industry Trends and Challenges to Drive Sector Forward - 3rd Watch News

Global Stem Cells Market 2020 by Manufacturers, Regions, Type and Application, Forecast to 2026 aims to target the major concepts related to market growth, major types, and various end users applicable, regional analysis, productivity structure, current market situation. The market report is a proficient and deep analysis of the present situation and challenges. The report offers analysis with regards to the past and current market situation of the global Stem Cells market. The report highlights all introducing income segmentation and also a firm sketch of the top players. It comprises streamlined financial data obtained from various research sources. The report analyzes the market players, sub-segments and sections, product category, and major improvements in the market.

Overview of The Report:

Top players are examined for revenue areas manufacturing, market rivalry, capacity, sales (value), moderate price, fabricating base supply and market share, and product types. The report also computes the limits and strong points of the players. The report studies key opportunities in the market and segmentation of market size, by volume and value, on the basis of application type and geography. The report focuses on innovative trends, implementing reasonable pricing stats in the competitive market. The overall description of the global Stem Cells market will assist our viewers to comprehend the market in the best way. It sheds light on the industry parameters by accessing the market growth, consumption volume, the upcoming market trends, and the different prices variation for the forecast year from 2020 to 2026.

NOTE: Our analysts monitoring the situation across the globe explains that the market will generate remunerative prospects for producers post COVID-19 crisis. The report aims to provide an additional illustration of the latest scenario, economic slowdown, and COVID-19 impact on the overall industry.

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The report covers a number of the players in the market, including: CCBC, Vcanbio, Boyalife, Beikebiotech,

Segmentation by product type and analysis of the market: Umbilical Cord Blood Stem Cell, Embryonic Stem Cell, Adult Stem Cell, Other

Segmentation by application and analysis of the market: Diseases Therapy, Healthcare

The scope of the report covers market eventualities to a comparative rating between major players, price, and profit of the required market regions. This report covers North America (United States, Canada and Mexico), Europe (Germany, France, UK, Russia and Italy), Asia-Pacific (China, Japan, Korea, India and Southeast Asia), South America (Brazil, Argentina, Colombia etc.), Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa). It focuses on the foremost and the progressing countries from every region in detail.

The report represents the ongoing marketing trends that are faced by the market competitors, the ups, and downs in the global Stem Cells market. Subsequently, it discovers the worlds main Stem Cells industry market requirements, for example, demand, distribution, profit, production, capacity, and promote growth speed and prediction, etc. The company further divides even the economy, by state also from application/type for its landscape analysis.

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Customization of the Report:

This report can be customized to meet the clients requirements. Please connect with our sales team ([emailprotected]), who will ensure that you get a report that suits your needs. You can also get in touch with our executives on +1-201-465-4211 to share your research requirements.

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Global Stem Cells Market 2020 | Demand and Scope with Outlook, Business Strategies, Challenges and Forecasts to 2026 - Cole of Duty

This report on Viral Vector Manufacturing market Added by Market Study Report, LLC, covers valuable insights based on market valuation, market size, revenue forecast, SWOT Analysis and regional outlook of this industry. The research also presents a precise summary of the industrys competitive spectrum, while drawing attention to the growth prospects and expansion plans adopted by key market players.

The research report on Viral Vector Manufacturing market is a comprehensive analysis of this business space and entails all the key aspects of the industry including net revenue estimates, present renumeration, periodic deliverables, segmental share, market size, and market trends.

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A brief assessment of the behavior pattern of the Viral Vector Manufacturing market over the forecast timeline has been cited in the report. Critical parameters such as growth drivers as well the expected growth rate followed during the study period are also documented in the report. It further elaborates on the potential growth aspects and restraints of this industry.

Main highlights of Viral Vector Manufacturing market report:

Geographical scrutiny of the Viral Vector Manufacturing market:

Viral Vector Manufacturing Market Segmentation:

Key insights presented in the report with respect to the regional outlook:

A thorough analysis of Viral Vector Manufacturing market with respect to the product landscape and application spectrum:

Product landscape:

Product types: Retroviral Vectors, Adenoviral Vectors, Adeno-associated Viral Vectors and Other Viral Vectors

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Main insights presented in the report:

Application landscape: IIII

Major discoveries of the report:

Other takeaways of Viral Vector Manufacturing market report:

Additional insight on the competitive outlook of the Viral Vector Manufacturing market:

Vendor base of the industry: BioReliance, Biovian, Cobra Biologics, UniQure, FinVector, Oxford BioMedica, FUJIFILM Diosynth Biotechnologies, MolMed, Lonza, MassBiologics and Brammer Bio

Vital parameters which define the competitive landscape of the Viral Vector Manufacturing market:

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Some of the Major Highlights of TOC covers:

Executive Summary

Manufacturing Cost Structure Analysis

Development and Manufacturing Plants Analysis of Viral Vector Manufacturing

Key Figures of Major Manufacturers

Related Reports:

2. Global Media for Stem Cell Market Growth 2020-2025Media for Stem Cell Market report characterize imperative Portion and contenders of the market regarding market estimate, volume, esteem. This report likewise covers every one of the locales and nations of the world, which demonstrates a territorial improvement status, it additionally incorporates Business Profile, Introduction, Revenue and so on.Read More: https://www.marketstudyreport.com/reports/global-media-for-stem-cell-market-growth-2020-2025

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Comprehensive Analysis on Viral Vector Manufacturing Market based on types and a - GroundAlerts.com

Global Precision Medicine Marketto grow with a substantial CAGR in the forecast period of 2019-2026. Growing prevalence of cancer worldwide and accelerating demand of novel therapies to prevent of cancer related disorders are the key factors for lucrative growth of market

Key Market Players:

Few of the major competitors currently working in the global precision medicine market are Neon Therapeutics, Moderna, Inc, Merck & Co., Inc, Bayer AG, PERSONALIS INC, GENOCEA BIOSCIENCES, INC., F. Hoffmann-La Roche Ltd, CureVac AG, CELLDEX THERAPEUTICS, BIONTECH SE, Advaxis, Inc, GlaxoSmithKline plc, Bioven International Sdn Bhd, Agenus Inc., Immatics Biotechnologies GmbH, Immunovative Therapies, Bristol-Myers Squibb Company, Gritstone Oncology, NantKwest, Inc among others.

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Global Precision Medicine MarketBy Application (Diagnostics, Therapeutics and Others), Technologies (Pharmacogenomics, Point-of-Care Testing, Stem Cell Therapy, Pharmacoproteomics and Others), Indication (Oncology, Central Nervous System (CNS) Disorders, Immunology Disorders, Respiratory Disorders, Others), Drugs (Alectinib, Osimertinib, Mepolizumab,Aripiprazole lauroxil and Others), Route of Administration (Oral,Injectable), End- Users (Hospitals, Homecare, Specialty Clinics, Others), Geography (North America, South America, Europe, Asia-Pacific, Middle East and Africa) Industry Trends and Forecast to 2026

Competitive Analysis:

The precision medicine market is highly fragmented and is based on new product launches and clinical results of products. Hence the major players have used various strategies such as new product launches, clinical trials, market initiatives, high expense on research and development, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares of mass spectrometry market for global, Europe, North America, Asia Pacific and South America.

Market Drivers

Market Restraints

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Market Definition:

Precision medicines is also known as personalized medicines is an innovative approach to the patient care for disease treatment, diagnosis and prevention base on the persons individual genes. It allows doctors or physicians to select treatment option based on the patients genetic understanding of their disease.

According to the data published in PerMedCoalition, it was estimated that the USFDA has approved 25 novels personalized medicines in the year of 2018. These growing approvals annually by the regulatory authorities and rise in oncology and CNS disorders worldwide are the key factors for market growth.

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Key Developments in the Market:

Competitive Analysis:

Global precision medicine market is highly fragmented and the major players have used various strategies such as new product launches, expansions, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares of global precision medicine market for Global, Europe, North America, Asia-Pacific, South America and Middle East & Africa.

Market Segmentation:

By technology:-big data analytics, bioinformatics, gene sequencing, drug discovery, companion diagnostics, and others.

By application:- oncology, hematology, infectious diseases, cardiology, neurology, endocrinology, pulmonary diseases, ophthalmology, metabolic diseases, pharmagenomics, and others.

On the basis of end-users:- pharmaceuticals, biotechnology, diagnostic companies, laboratories, and healthcare it specialist.

On the basis of geography:- North America & South America, Europe, Asia-Pacific, and Middle East & Africa. U.S., Canada, Germany, France, U.K., Netherlands, Switzerland, Turkey, Russia, China, India, South Korea, Japan, Australia, Singapore, Saudi Arabia, South Africa, and Brazil among others.

In 2017, North America is expected to dominate the market.

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COVID-19 UPDATE: Precision Medicine Market 2020: Industry Analysis and Detailed Profiles of Top Industry Players are Neon Therapeutics, Moderna, Inc,...

This Global Bone Marrow Market research report carries out the methodical and comprehensive market research study that puts forth the facts and figures linked with any subject about Bone Marrow Industry. Moreover, this business research report highlights numerous industry verticals such as company profile, contact details of the manufacturer, product specifications, geographical scope, production value, market structures, recent developments, revenue analysis, market shares and potential sales volume of the company. With the competitive analysis of the major players in the market, the Bone Marrow report lends a hand to businesses in taking better moves for improving their product and sales.

Additionally, this comprehensive Bone Marrow market report explains a better market perspective in terms of product trends, marketing strategy, future products, new geographical markets, future events, sales strategies, customer actions, or behaviors. The report fetches into focus studies about market definition, market segmentation, and competitive analysis in the market. As per the DBMR team predictions cited in this report, the market will grow with a specific CAGR value in the forecast. This Bone Marrow report also covers a very important aspect which is a competitive intelligence and with these businesses can gain a competitive advantage to thrive in the market.

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The major players covered in the report are:

Abbott; QIAGEN; Diazyme Laboratories, Inc.; Sanofi; CSL; STEMCELL Technologies Inc.; Lonza; HemaCare; PromoCell GmbH; Mesoblast Ltd; Lifeline Cell Technology, an International Stem Cell Company; Cellular Dynamics International, Inc.; ReachBio LLC; ATCC; Merck KGaA; Discovery Life Sciences; AllCells; ReeLabs Pvt. Ltd. and Gamida Cell.

Abstract

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The countries covered in the Bone Marrow Market report are:

Purposes Behind Buying Bone Marrow Market Report:-

The classification of the global Bone Marrow Market is done based on the product type, segments, and end-users. The report provides an analysis of each segment together with the prediction of their development in the upcoming period. Additionally, the latest research report studies various segments of the global Bone Marrow Market in the anticipated period.

Also, Research Report Examines:

Lastly, with a team of vivacious industry professionals, we offer our clients with high-value market research that, in turn, would aid them to decipher new market avenues together with new strategies to take hold of the market share.

Thanks for reading this article; you can also get individual chapter wise section or region wise report version like North America, Europe, or Asia.

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Bone Marrow Market Is Slated To Grow Rapidly In The Coming Years - Cole of Duty